BMRB Entry 6389
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR6389
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Title: Acting on the Number of Molecular Contacts between Maurotoxin and Kv1.2 Channel Impacts Ligand Affinity PubMed: 15971207
Deposition date: 2004-11-15 Original release date: 2005-08-22
Authors: McBarek, Sarrah; Chagot, Benjamin; Andreotti, Nicolas; Visan, Violeta; Mansuelle, Pascal; Grissmer, Stephan; Marrakchi, Mohamed; El Ayeb, Mohamed; Sampieri, Francois; Darbon, Herve; Fajloun, Ziad; De Waard, Michel; Sabatier, Jean-Marc
Citation: M'Barek, Sarrah; Chagot, Benjamin; Andreotti, Nicolas; Visan, Violeta; Mansuelle, Pascal; Grissmer, Stephan; Marrakchi, Mohamed; El Ayeb, Mohamed; Sampieri, Francois; Darbon, Herve; Fajloun, Ziad; De Waard, Michel; Sabatier, Jean-Marc. "Increasing the Molecular Contacts between Maurotoxin and Kv1.2 Channel Augments Ligand Affinity" Proteins 60, 401-411 (2005).
Assembly members:
BuTX-MTX, polymer, 41 residues, Formula weight is not available
Natural source: Common Name: scorpion Taxonomy ID: 6887 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Tityus serrulatus
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
BuTX-MTX: WCSTCLDLACTGSKDCYAPC
RKQTGCPNAKCINKSCKCYG
C
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 208 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | BuTX-MTX | 1 |
Entities:
Entity 1, BuTX-MTX 41 residues - Formula weight is not available
| 1 | TRP | CYS | SER | THR | CYS | LEU | ASP | LEU | ALA | CYS | ||||
| 2 | THR | GLY | SER | LYS | ASP | CYS | TYR | ALA | PRO | CYS | ||||
| 3 | ARG | LYS | GLN | THR | GLY | CYS | PRO | ASN | ALA | LYS | ||||
| 4 | CYS | ILE | ASN | LYS | SER | CYS | LYS | CYS | TYR | GLY | ||||
| 5 | CYS |
Samples:
sample_1: BuTX-MTX mM
conditions_1: pH: 3; temperature: 290 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 1H COSY | sample_1 | not available | conditions_1 |
| 1H TOCSY | sample_1 | not available | conditions_1 |
| 1H NOESY | sample_1 | not available | conditions_1 |
Software:
xwinnmr v2.1, BRUKER -
NMR spectrometers:
- BRUKER DRX 500 MHz
Related Database Links:
| PDB |