BMRB Entry 4200
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR4200
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Title: NMR Solution Structure of the c-Myc-Max Heterodimeric Leucine Zipper
Deposition date: 1998-09-10 Original release date: 2008-03-24
Authors: Lavigne, P.; Crump, M.; Gagne, S.; Hodges, R.; Kay, C.; Sykes, B.
Citation: Lavigne, P.; Crump, M.; Gagne, S.; Hodges, R.; Kay, C.; Sykes, B.. "Insights into the Mechanism of Heterodimerization from the 1H-NMR Solution Structure of the c-Myc-Max Heterodimeric Leucine Zipper" J. Mol. Biol. 281, 165-181 (1998).
Assembly members:
Leucine Zipper domain of c-Myc, polymer, 34 residues, 3846 Da.
Max Leucine Zipper Domain, polymer, 34 residues, 3793 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
Leucine Zipper domain of c-Myc: XCGGVQAEEQKLISEEDLLR
KRREQLKHKLEQLX
Max Leucine Zipper Domain: XCGGMRRKNDTHQQDIDDLK
RQNALLEQQVRALX
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 377 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | c-Myc LZ Chain A | 1 |
| 2 | Max LZ Chain B | 2 |
Entities:
Entity 1, c-Myc LZ Chain A 34 residues - 3846 Da.
| 1 | ACE | CYS | GLY | GLY | VAL | GLN | ALA | GLU | GLU | GLN | ||||
| 2 | LYS | LEU | ILE | SER | GLU | GLU | ASP | LEU | LEU | ARG | ||||
| 3 | LYS | ARG | ARG | GLU | GLN | LEU | LYS | HIS | LYS | LEU | ||||
| 4 | GLU | GLN | LEU | NH2 |
Entity 2, Max LZ Chain B 34 residues - 3793 Da.
| 1 | ACE | CYS | GLY | GLY | MET | ARG | ARG | LYS | ASN | ASP | ||||
| 2 | THR | HIS | GLN | GLN | ASP | ILE | ASP | ASP | LEU | LYS | ||||
| 3 | ARG | GLN | ASN | ALA | LEU | LEU | GLU | GLN | GLN | VAL | ||||
| 4 | ARG | ALA | LEU | NH2 |
Samples:
sample_one: Leucine Zipper domain of c-Myc 1.0 mM; potassium phosphate 50 mM; H2O 90%; D2O 10%; KCl 50 mM; DSS 1 mM
sample_conditions: ionic strength: 0.1 M; pH: 4.8 na; temperature: 298.15 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| not available | sample_one | not available | sample_conditions |
Software:
VNMR v5.2 -
NMR spectrometers:
- Varian VXR 500 MHz
- Varian Unity 600 MHz