BMRB Entry 25206
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PDB ID:
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR25206
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Title: Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
Deposition date: 2014-09-08 Original release date: 2015-09-21
Authors: Curtidor, Hernando; Torres, Mary Helena; Alba, Martha Patricia; Patarroyo, Manuel Elkin
Citation: Curtidor, Hernando; Torres, Mary Helena; Alba, Martha Patricia; Patarroyo, Manuel Elkin. "Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys" Biol. Chem. 388, 25-36 (2007).
Assembly members:
entity, polymer, 20 residues, 2401.756 Da.
Natural source: Common Name: not available Taxonomy ID: not available Superkingdom: not available Kingdom: not available Genus/species: not available not available
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
entity: ESAKHMFDRIGKDVYDKVKE
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 109 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | entity | 1 |
Entities:
Entity 1, entity 20 residues - 2401.756 Da.
| 1 | GLU | SER | ALA | LYS | HIS | MET | PHE | ASP | ARG | ILE | |
| 2 | GLY | LYS | ASP | VAL | TYR | ASP | LYS | VAL | LYS | GLU |
Samples:
sample_1: entity8 – 10 mM; H2O 70%; trifluoroethanol 30%
sample_conditions_1: pH: 3.7; pressure: 1 atm; temperature: 295 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 2D DQF-COSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H TOCSY | sample_1 | isotropic | sample_conditions_1 |
| 2D 1H-1H NOESY | sample_1 | isotropic | sample_conditions_1 |
Software:
InsightII, Accelrys Software Inc. - geometry optimization, refinement
NMR spectrometers:
- Bruker DRX 500 MHz