BMRB Entry 19476
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PDB ID:
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19476
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Title: NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis PubMed: 24567324
Deposition date: 2013-09-01 Original release date: 2014-03-03
Authors: Maiti, M.; Lescrinier, E.; Herdewijn, P.; Lebbe, E.; Peigneur, S.; D'Souza, L.; Tytgat, J.
Citation: Lebbe, Eline; Peigneur, Steve; Maiti, Mohitosh; Devi, Prabha; Ravichandran, Samuthirapandian; Lescrinier, Eveline; Ulens, Chris; Waelkens, Etienne; Herdewijn, Lisette; Tytgat, Piet. "Structure-Function Elucidation of a New -Conotoxin, Lo1a, from Conus longurionis." J. Biol. Chem. 289, 9573-9583 (2014).
Assembly members:
CONOTOXIN_LO1A, polymer, 18 residues, 1937.117 Da.
Natural source: Common Name: Conus longurionis Taxonomy ID: 1077918 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Conus longurionis
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
CONOTOXIN_LO1A: EGCCSNPACRTNHPEVCD
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 48 |
| 1H chemical shifts | 103 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | CONOTOXIN LO1A | 1 |
Entities:
Entity 1, CONOTOXIN LO1A 18 residues - 1937.117 Da.
| 1 | GLU | GLY | CYS | CYS | SER | ASN | PRO | ALA | CYS | ARG | ||||
| 2 | THR | ASN | HIS | PRO | GLU | VAL | CYS | ASP |
Samples:
sample: CONOTOXIN LO1A 2.6 mM
sample_conditions_1: pH: 5.9; pressure: 1 atm; temperature: 278 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| 2D DQF-COSY | sample | isotropic | sample_conditions_1 |
| 2D 1H-1H NOESY | sample | isotropic | sample_conditions_1 |
| 2D 1H-1H TOCSY | sample | isotropic | sample_conditions_1 |
| 2D 1H-13C HSQC aliphatic | sample | isotropic | sample_conditions_1 |
| 2D 1H-13C HSQC aromatic | sample | isotropic | sample_conditions_1 |
Software:
X-PLOR NIH v2.25, SCHWIETERS, KUSZEWSKI, TJ - refinement
TOPSPIN v2.1, Bruker - processing
NMR spectrometers:
- BRUKER AVANCE 600 MHz